The Adsorption Effect of Different Resins with Epothilones

Jian CAO, Can LI, Kun-lun LI, Xin-li LIU, Lin ZHAO

Abstract


In this paper, we first found a mixed resin with better adsorption effect than XAD-16 from 30 kinds of domestic resins. When two kinds of mixed resins (XD-5: D202=7:3) were mixed, the production of Ascomycetes So 2161 was produced. The yield of epothilone A and B increased by 252% and 262%, respectively, compared to the yield of the macroporous adsorption resin XAD-16 alone. Then the effect of mixed resin on the synthesis of epothilone was further studied. It was found through research that the macroporous adsorption resin XD-5 has better adsorption capacity for epothilone. The anion exchange resin D202 significantly promoted the growth of the Sorangium cellulosum.

Keywords


Sorangium cellulosum, Adsorption, Macroporous resin, Anion exchange resin, Epothilones


DOI
10.12783/dtetr/amee2018/25365

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