The Effect and Mechanism of Apopotosis on Human Lung Cancer A549 Cells Induced by Trillin Through AKT/PI3K Pathway

Guo-quan WANG, Xu CHAO, Sha LI, Lin-zhong YU, En-hu ZHANG

Abstract


Cytotoxic activity of Trillin (Tr) was determined by cck-8 assay at various concentrations ranging from 10 to 40 μg/ml on A549 cells. The Apoptosis and its mechanism induced by Trillin was investigated. The results showed Trillin displayed the marked inhibition effect to A549 cells and the IC50 value is 28.6μg/ml for 24 hour. The protein expressions of PI3K and Akt increased in A549 cells treated with Trillin. These data suggest that apoptotic effect of Trillin is mediated through AKT/PI3K pathway in A549 cells.

Keywords


Apoptosis, Trillin, A549, AKT/PI3K pathway


DOI
10.12783/dtetr/amee2018/25360

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