Cholinesterase and Human Lung Cancer Cells (A-549) Inhibitory Activity of the Cassava Peel of Euphorbiaceae in Vitro

Abstract

To investigate 10 different extracts of cassava peel on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor activity in vitro and inhibition activity of human lung cancer cells (A-549) in vitro. At the concentration of 500μg/ml, the AChE inhibitory activity of S5 was the highest, its inhibition rate could reach (76.45 ± 0.50)%, AChE inhibitory activity of S8 was the lowest, inhibition rate was (28.29 ± 1.23)%; (Ⅱ) At the concentration of 500μg/ml, S4 had the highest inhibitory activity, the BuChE inhibition could achieved (103.06 ± 1.46)%, followed by the S10, the BuChE inhibition rate was (100.07 ± 1.11)%, S6 had the lowest BuChE inhibitory activity , its BuChE inhibition rate was (8.27 ± 0.74)%; (Ⅲ) At the concentration of 50μg/ml, S3 had the strongest A-549 inhibitory effect, inhibition rate (69.71 ± 1.18)%, the lowest A-549 inhibitory activity was S9, its A-549 inhibition rate (10.72 ± 1.03)%.